c4pain.com

PAIN - Vol. 149

Topographical mapping of pressure pain thresholds over knee in a patient with osteoarthritis.

Puplished in PAIN, VOL. 149, Number 3. June 2010

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Assessing pain sensitisation in Osteoarthritis

Most recent publication on assessing pain sensitisation in osteoarthritis (OA) provides new tools for evaluating durg efficacy in OA: Arendt-Nielsen L, Nie H, Laursen MB, Laursen BS, Madeleine P, Simonsen OH, Graven-Nielsen T. Sensitization in patients with painful knee osteoarthritis. Pain. 2010 Jun;149(3):573-81.

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C4Pain will present at the Pain Therapeutics Conference, London, June, 2010

C4Pain will present "Pain-biomarkers and read-outs applied in early drug development" at the Pain Therapeutics conference 7th to 8th June 2010, Crowne Plaza - The City, London, United Kingdom.

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C4Pain and Aepodia host a workshop at Exploratory Clinical Development World Europe 2010, London, May 2010

C4Pain and Aepodia have organised a workshop at Exploratory Clinical Development World Europe 2010, London, May 2010. on human pain bio-markers in early drug development

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C4Pain at 16th World Congress of Basic and Clinical Pharmacology

C4Pain will be present at 16th World Congress of Basic and Clinical Pharmacology conference in Copenhagen, WorldPharma, July 2010. Look for teyh workshop: Translational human bio-markers for pain and disease severity in drug development.

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Publications 2010

Recent Publications

Schytz HW, Holst H, Arendt-Nielsen L, Olesen J, Ashina M. Cutaneous nociception and neurogenic inflammation evoked by PACAP38 and VIP. J Headache Pain. 2010 May 9. In press

Xu YM, Ge HY, Arendt-Nielsen L. Sustained Nociceptive Mechanical Stimulation of Latent Myofascial Trigger Point Induces Central Sensitization in Healthy Subjects. J Pain. 2010 May 5. In press

Petersen LJ, Lyngholm AM, Arendt-Nielsen L. A novel model of inflammatory pain in human skin involving topical application of sodium lauryl sulfate. Inflamm Res. 2010 Apr 1. In press

Olesen SS, Brock C, Krarup AL, Funch-Jensen P, Arendt-Nielsen L, Wilder-Smith OH, Mohr Drewes A. Descending Inhibitory Pain Modulation Is Impaired in Patients With Chronic Pancreatitis. Clin Gastroenterol Hepatol. 2010 Mar 19. In press

Torisu T, Wang K, Svensson P, Laat AD, Tanaka M, Shimada A, Ikoma A, Murata H, Arendt-Nielsen L. Effects of eccentric jaw exercise on temporal summation in jaw-closing muscles of healthy subjects. Eur J Pain. 2010, in press

Fernández-de-Las-Peñas C, Madeleine P, Martínez-Perez A, Arendt-Nielsen L, Jiménez-García R, Pareja JA. Pressure pain sensitivity topograhical maps reveal bilateral hyperalgesia of the hands in patients with unilateral carpal tunnel syndrome. Arthritis Care Res (Hoboken). 2010 Mar 16. In press

van den Broeke EN, van Rijn CM, Biurrun Manresa JA, Andersen OK, Arendt-Nielsen L, Wilder-Smith OH. Neurophysiological Correlates of Nociceptive Heterosynaptic Long-Term Potentiation in Humans. J Neurophysiol. 2010 Feb 17. In press

Wang K, Svensson P, Sessle BJ, Cairns BE, Arendt-Nielsen L. Interactions of glutamate and capsaicin-evoked muscle pain on jaw motor functions of men. Clin Neurophysiol. 2010 Feb 11. in press

Binderup AT, Arendt-Nielsen L, Madeleine P. Cluster analysis of pressure pain threshold maps from the trapezius muscle. Comput Methods Biomech Biomed Engin. 2010 Feb 8:1. In press

Baad-Hansen L, Arima T, Arendt-Nielsen L, Neumann-Jensen B, Svensson P. Quantitative sensory tests before and 1(1/2) years after orthognathic surgery: a cross-sectional study. J Oral Rehabil. 2010 Jan 25. In press

Arendt-Nielsen L, Nie H, Laursen MB, Laursen BS, Madeleine P, Simonsen OH, Graven-Nielsen T. Sensitization in patients with painful knee osteoarthritis. Pain. 2010 Jun;149(3):573-81.

Fernández-Carnero J, Ge HY, Kimura Y, Fernández-de-Las-Peñas C, Arendt-Nielsen L. Increased spontaneous electrical activity at a latent myofascial trigger point after nociceptive stimulation of another latent trigger point. Clin J Pain. 2010 Feb;26(2):138-43.

Yarnitsky D, Arendt-Nielsen L, Bouhassira D, Edwards RR, Fillingim RB, Granot M, Hansson P, Lautenbacher S, Marchand S, Wilder-Smith O.Recommendations on terminology and practice of psychophysical DNIC testing. Eur J Pain. 2010 Apr;14(4):339.

Hidalgo-Lozano A, Fernández-de-las-Peñas C, Alonso-Blanco C, Ge HY, Arendt-Nielsen L, Arroyo-Morales M. Muscle trigger points and pressure pain hyperalgesia in the shoulder muscles in patients with unilateral shoulder impingement: a blinded, controlled study. Exp Brain Res. 2010 May;202(4):915-25.

Siegenthaler A, Eichenberger U, Schmidlin K, Arendt-Nielsen L, Curatolo M. What does local tenderness say about the origin of pain? An investigation of cervical zygapophysial joint pain. Anesth Analg. 2010 Mar;110(3):923-7.

Komiyama O, Wang K, Svensson P, Arendt-Nielsen L, De Laat A, Kawara M. Magnetic and electric stimulation to elicit the masseteric exteroceptive suppression period. Clin Neurophysiol. 2010 May;121(5):793-9.

Wang YH, Ding XL, Zhang Y, Chen J, Ge HY, Arendt-Nielsen L, Yue SW. Ischemic compression block attenuates mechanical hyperalgesia evoked from latent myofascial trigger points. Exp Brain Res. 2010 Apr;202(2):265-70.

Andersen H, Ge HY, Arendt-Nielsen L, Danneskiold-Samsøe B, Graven-Nielsen T. Increased trapezius pain sensitivity is not associated with increased tissue hardness. J Pain. 2010 May;11(5):491-9.

Fernández-de-las-Peñas C, Galán-del-Río F, Ortega-Santiago R, Jiménez-García R, Arendt-Nielsen L, Svensson P. Bilateral thermal hyperalgesia in trigeminal and extra-trigeminal regions in patients with myofascial temporomandibular disorders. Exp Brain Res. 2010 Apr;202(1):171-9.

Fernández-Carnero J, Binderup AT, Ge HY, Fernández-de-las-Peñas C, Arendt-Nielsen L, Madeleine P. Pressure pain sensitivity mapping in experimentally induced lateral epicondylalgia. Med Sci Sports Exerc. 2010 May;42(5):922-7.

La Touche R, Fernández-de-Las-Peñas C, Fernández-Carnero J, Díaz-Parreño S, Paris-Alemany A, Arendt-Nielsen L. Bilateral mechanical-pain sensitivity over the trigeminal region in patients with chronic mechanical neck pain. J Pain. 2010 Mar;11(3):256-63.

Babiloni C, Capotosto P, Del Percio C, Babiloni F, Petrini L, Buttiglione M, Cibelli G, Marusiak J, Romani GL, Arendt-Nielsen L, Rossini PM. Sensorimotor interaction between somatosensory painful stimuli and motor sequences affects both anticipatory alpha rhythms and behavior as a function of the event side. Brain Res Bull. 2010 Mar 16;81(4-5):398-405.

Zhang Y, Boudreau S, Wang M, Wang K, Sessle B, Arendt-Nielsen L, Svensson P. Effects of periodontal afferent inputs on corticomotor excitability in humans. J Oral Rehabil. 2010 Jan;37(1):39-47.

Holst H, Arendt-Nielsen L, Mosbech H, Vesterhauge S, Elberling J. The capsaicin cough reflex in patients with symptoms elicited by odorous chemicals. Int J Hyg Environ Health. 2010 Jan;213(1):66-71.

Koutris M, Naeije M, Lobbezoo F, Wang K, Arendt-Nielsen L, Svensson P, Farina D. Normalization reduces the spatial dependency of the jaw-stretch reflex activity in the human masseter muscle. Muscle Nerve. 2010 Jan;41(1):78-84.

Gravesen FH, Gregersen H, Arendt-Nielsen L, Drewes AM. Reproducibility of axial force and manometric recordings in the oesophagus during wet and dry swallows. Neurogastroenterol Motil. 2010 Feb;22(2):142-9.

Falla D, Andersen H, Danneskiold-Samsøe B, Arendt-Nielsen L, Farina D. Adaptations of upper trapezius muscle activity during sustained contractions in women with fibromyalgia. J Electromyogr Kinesiol. 2010 Jun;20(3):457-64

Brock C, Andresen T, Frøkjaer JB, Gale J, Olesen AE, Arendt-Nielsen L, Drewes AM. Central pain mechanisms following combined acid and capsaicin perfusion of the human oesophagus. Eur J Pain. 2010 Mar;14(3):273-81.

Neziri AY, Andersen OK, Petersen-Felix S, Radanov B, Dickenson AH, Scaramozzino P, Arendt-Nielsen L, Curatolo M. The nociceptive withdrawal reflex: normative values of thresholds and reflex receptive fields. Eur J Pain. 2010 Feb;14(2):134-41.

Barascuk N, Skjøt-Arkil H, Register TC, Larsen L, Byrjalsen I, Christiansen C, Karsdal MA. Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processes. BMC Cardiovasc Disord. 2010 Apr 21;10:19.

Nielsen M, Pettersen PC, Alexandersen P, Karemore G, Raundahl J, Loog M, Christiansen C. Breast density changes associated with postmenopausal hormone therapy: post hoc radiologist- and computer-based analyses. Menopause. 2010 Apr 6. In press

Christiansen C, Skotland T. Changes of protein solutions during storage: a study of albumin pharmaceutical preparations. Biotechnol Appl Biochem. 2010 Mar 5;55(3):121-30.

Qvist P, Christiansen C, Karsdal MA, Madsen SH, Sondergaard BC, Bay-Jensen AC. Application of biochemical markers in development of drugs for treatment of osteoarthritis. Biomarkers. 2010 Feb;15(1):1-19.

Højlund K, Elsborg R, Poulsen MK, Selmar PE, Holst JJ, Christiansen C, Beck-Nielsen H. Automated detection of hypoglycemia-induced EEG changes recorded by subcutaneous electrodes in subjects with type 1 diabetes--the brain as a biosensor. Diabetes Res Clin Pract. 2010 Apr;88(1):22-8.

Keller M, Lerch M, Britschgi M, Tâche V, Gerber BO, Lüthi M, Lochmatter P, Kanny G, Bircher AJ, Christiansen C, Pichler WJ. Processing-dependent and -independent pathways for recognition of iodinated contrast media by specific human T cells. Clin Exp Allergy. 2010 Feb;40(2):257-68.

Alexandersen P, Karsdal MA, Christiansen C. Long-term prevention with hormone-replacement therapy after the menopause: which women should be targeted? Womens Health (Lond Engl). 2009 Nov;5(6):637-47.

Karsdal MA, Byrjalsen I, Henriksen K, Riis BJ, Christiansen C. Investigations of inter- and intraindividual relationships between exposure to oral salmon calcitonin and a surrogate marker of pharmacodynamic efficacy. Eur J Clin Pharmacol. 2010 Jan;66(1):29-37.

Karsdal MA, Byrjalsen I, Henriksen K, Riis BJ, Lau EM, Arnold M, Christiansen C. The effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized study.Osteoarthritis Cartilage. 2010 Feb;18(2):150-9

Bay-Jensen AC, Sondergaard BC, Christiansen C, Karsdal MA, Madsen SH, Qvist P. Biochemical markers of joint tissue turnover. Assay Drug Dev Technol. 2010 Feb;8(1):118-24.

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Lars Arendt-Nielsen participate in Science Webinar Series

Lars Arendt-Nielsen participate in Science Webinar Series about Translational Medical Research in Denmark, Wednesday, February 10, 2010**, ****5 p.m. CET.

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Translational Pain Research in Denmark, Science Magazine issue 15th January 2010

Read the full article by clicking here

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Publications 2009

Arendt-Nielsen, Lars ; Olesen, Anne Estrup ; Ståhl, Camilla ; Menzaghi, Frédérique ; Kell, Sherron; Wong, Gilbert Y. ; Drewes, Asbjørn Mohr.
Analgesic Efficacy of Peripheral kappa-Opioid Receptor Agonist CR665 Compared to Oxycodone in a Multi-modal, Multi-tissue Experimental Human Pain Model Selective Effect on Visceral Pain.
In: Anesthesiology. 2009 ; Vol. 111, No. 3, p. 616-624

Arendt-Nielsen, Lars ; Yarnitsky, David.
Experimental and clinical applications of quantitative sensory testing applied to skin, muscles and viscera.
In: Journal of Pain. 2009 ; Vol. 10, No. 6, JUN. p. 556-572

Arendt-Nielsen, Lars ; Hoeck, Hans Christian ; Karsdal, Morten A. ; Christiansen, Claus.
Role of calcitonin in management of musculoskeletal pain.
In: Rheumatology Reports. 2009 ; Vol. 1, No. 1, p. 39-42

Arima, Taro ; Arendt-Nielsen, Lars ; Minagi, Shogo ; Svensson, Peter.
Effect of capsaicin-evoked jaw-muscle pain on intramuscular blood-flow.
In: Archives of Oral Biology. 2009 ; Vol. 54, No. 3, MAR. p. 241-249

Babiloni, Claudio ; Capotosto, Pablo ; Del Percio, Claudio ; Petrini, Laura ; Buttiglione, Maria ; Cibelli, Giuseppe ; Marusiak, Jaroslaw ; Romani, Gian Luca ; Arendt-Nielsen, Lars ; Rossini, Paolo Maria.
Sensorimotor interaction between somatosensory painful stimuli and motor sequences affects both anticipatory alpha rhythms and behavior as a function of the event side.
In: Brain Research Bulletin. 2009 ; E-Pub ahead of print

Bergadano, Alessandra ; Andersen, Ole K. ; Arendt-Nielsen, Lars ; Spadavecchia, Claudia.
Modulation of nociceptive withdrawal reflexes evoked by single and repeated nociceptive stimuli in conscious dogs by low-dose acepromazine.
In: Veterinary Anaesthesia and Analgesia. 2009 ; Vol. 36, No. 3, MAY. p. 261-272

Bergadano, Alessandra ; Andersen, Ole K. ; Arendt-Nielsen, Lars ; Theurillat, Regula ; Thormann, Wolfgang ; Spadavecchia, Claudia.
Plasma levels of a low-dose constant-rate-infusion of ketamine and its effect on single and repeated nociceptive stimuli in conscious dogs.
In: Veterinary Journal. 2009 ; Vol. 182, No. 2, NOV. p. 252-260

Binderup, Asbjørn Thalund ; Arendt-Nielsen, Lars ; Madeleine, Pascal.
Pressure pain threshold mapping of the trapezius muscle reveals heterogeneity in the distribution of muscular hyperalgesia after eccentric exercise.
In: European Journal of Pain. 2009 ; E-Pub ahead of print

Boudreau, S. A. ; Wang, Kelun ; Svensson, Peter ; Sessle, B. J. ; Arendt-Nielsen, Lars.
Vascular and psychophysical effects of topical capsaicin application to orofacial tissues.
In: Journal of Orofacial Pain. 2009 ; Vol. 23, No. 3, SUM. p. 253-264

Brock, Christina ; Andresen, Trine ; Frøkjær, Jens Brøndum ; Gale, Jeremy ; Olesen, Anne Estrup ; Arendt-Nielsen, Lars ; Drewes, Asbjørn Mohr.
Central pain mechanisms following combined acid and capsaicin perfusion of the human oesophagus.
In: European Journal of Pain. 2009 ; E-Pub ahead of print

Brock, Christina ; Arendt-Nielsen, Lars ; Wilder-Smith, Oliver ; Drewes, Asbjørn Mohr.
Sensory testing of the human gastrointestinal tract.
In: World Journal of Gastroenterology. 2009 ; Vol. 15, No. 2, JAN 14. p. 151-159

Buchgreitz, L. ; Egsgaard, Line Lindhardt ; Jensen, R. ; Arendt-Nielsen, Lars ; Bendtsen, L.
Abnormal brain processing of pain in migraine without aura : a high-density EEG brain mapping study.
In: Cephalalgia. 2009 ; E-Pub ahead of print

Cuadrado, M.L. ; Valle, B. ; Fernández-de-las-Peñas, C. ; Madeleine, Pascal ; Barriga, F.J. ; Arias, J.A. ; Arendt-Nielsen, Lars ; Pareja, J.A..
Pressure pain sensitivity of the scalp in patients with nummular headache : a cartographic study.
In: Cephalalgia. 2009 ; E-Pub ahead of print

de la Llave-Rincón, Ana Isabel ; Fernandez-de-las-Penas, Cesar ; Fernández-Carnero, Josué ; Padua, Luca ; Arendt-Nielsen, Lars ; Pareja, Juan A..
Bilateral hand/wrist heat and cold hyperalgesia, but not hypoesthesia, in unilateral carpal tunnel syndrome.
In: Experimental Brain Research. 2009 ; Vol. 198, No. 4, OCT. p. 455-463

Defrin, Ruth ; Petrini, Laura ; Arendt-Nielsen, Lars.
Spatial summation of thermal sensations depends on skin type and skin sensitivity.
In: Experimental Brain Research. 2009 ; Vol. 198, No. 1, SEP. p. 29-36

Egsgaard, Line Lindhardt ; Wang, Li ; Arendt-Nielsen, Lars.
Volunteers with high versus low alpha EEG have different pain-EEG relationship : a human experimental study.
In: Experimental Brain Research. 2009 ; Vol. 193, No. 3, MAR. p. 361-369

Falla, Deborah Lorraine ; Andersen, Helle ; Danneskiold-Samsøe, Bente ; Arendt-Nielsen, Lars ; Farina, Dario.
Adaptations of upper trapezius muscle activity during sustained contractions in women with fibromyalgia.
In: Journal of Electromyography & Kinesiology. 2009 ; E-Pub ahead of print

Falla, Deborah Lorraine ; Arendt-Nielsen, Lars ; Farina, Dario.
The pain-induced change in relative activation of upper trapezius muscle regions is independent of the site of noxious stimulation.
In: Clinical Neurophysiology. 2009 ; Vol. 120, No. 1, JAN. p. 150-157

Fernández-Carnero, Josué ; Fernandez-de-las-Penas, Cesar ; Sterling, Michel ; Souvlis, Tina ; Arendt-Nielsen, Lars ; Vicenzino, Bill.
Exploration of the extent of somato-sensory impairment in patients with unilateral lateral epicondylalgia.
In: Journal of Pain. 2009 ; Vol. 10, No. 11, NOV. p. 1179-1185

Fernández-Carnero, Josué ; Binderup, Asbjørn Thalund ; Ge, Hong You ; Fernandez-de-las-Penas, Cesar ; Arendt-Nielsen, Lars ; Madeleine, Pascal.
Pressure pain sensitivity mapping in experimentally induced lateral epicondylalgia.
In: Medicine and Science in Sports and Exercise. 2009, E-Pub ahead of print

Fernández-Carnero, Josué ; Fernández-de-las-Peñas, César ; de la Llave-Rincón, Ana Isabel ; Ge, Hong You ; Arendt-Nielsen, Lars.
Widespread Mechanical Pain Hypersensitivity as Sign of Central Sensitization in Unilateral Epicondylalgia A Blinded, Controlled Study.
In: Clinical Journal of Pain. 2009 ; Vol. 25, No. 7, p. 555-561

Fernandez-de-las-Peñas, César ; Arendt-Nielsen, Lars ; Cuadrado, Maria Luz ; Pareja, Juan.
Generalized mechanical pain sensitivity over nerve tissues in patients with strictly unilateral migraine.
In: Clinical Journal of Pain. 2009 ; Vol. 25, No. 5, JUN. p. 401-406

Fernandez-de-las-Penas, Cesar ; de la Llave-Rincón, Ana Isabel ; Fernández-Carnero, Josué ; Cuadrado, María Luz ; Arendt-Nielsen, Lars ; Pareja, Juan A..
Bilateral widespread mechanical pain sensitivity in carpal tunnel syndrome : evidence of central processing in unilateral neuropathy.
In: Brain. 2009 ; Vol. 132, No. 6, JUN. p. 1472-1479

Fernandez-de-las-Penas, Cesar ; Galán-del-Río, Fernando ; Fernández-Carnero, Josué ; Pesquera, Jorge ; Arendt-Nielsen, Lars ; Svensson, Peter.
Bilateral widespread mechanical pain sensitivity in women with myofascial temporomandibular disorder : evidence of impairment in central nociceptive processing.
In: Journal of Pain. 2009 ; Vol. 10, No. 11, NOV. p. 1170-1178

Fernandez-de-las-Penas, Cesar ; Arendt-Nielsen, Lars.
Mechanical allodynia and hyperalgesia in nerve and muscles in chronic tension-type headache.
In: Future Neurology. 2009 ; Vol. 4, No. 1, p. 119-127

Fernandez-de-las-Penas, Cesar ; Caminero, Ana ; Madeleine, Pascal ; Guillem-Mesado, Amparo; Ge, Hong You ; Arendt-Nielsen, Lars ; Pareja, Juan A..
Multiple active myofascial trigger points and pressure pain sensitivity maps in the temporalis muscle are related in women with chronic tension type headache.
In: Clinical Journal of Pain. 2009 ; Vol. 25, No. 6, JUL-AUG. p. 506-512

Fernandez-de-las-Penas, Cesar ; Madeleine, Pascal ; Cuadrado, M. L. ; Ge, Hong You ; Arendt-Nielsen, Lars ; Pareja, J. A..
Pressure pain sensitivity mapping of the temporalis muscle revealed bilateral pressure hyperalgesia in patients with strictly unilateral migraine.
In: Cephalalgia. 2009 ; Vol. 29, No. 6, JUN. p. 670-676

Fernandez-de-las-Penas, Cesar ; Ge, Hong You ; Alonso-Blanco, Cristina ; González-Iglesias, Javier ; Arendt-Nielsen, Lars.
Referred pain areas of active myofascial trigger points in head, neck, and shoulder muscles, in chronic tension type headache.
In: Journal of Bodywork and Movement Therapies. 2009 ; E-Pub ahead of print

Frøkjær, Jens Brøndum ; Søfteland, Eirik ; Graversen, Carina ; Dimcevski, Georg ; Egsgaard, Line Lindhardt ; Arendt-Nielsen, Lars ; Drewes, Asbjørn Mohr.
Central processing of gut pain in diabetic patients with gastrointestinal symptoms.
In: Diabetes Care. 2009 ; Vol. 32, No. 7, JUL. p. 1274-1277

Gazerani, Parisa ; Pedersen, N. S. ; Drewes, Asbjørn Mohr ; Arendt-Nielsen, Lars.
Botulinum toxin type A reduces histamine-induced itch and vasomotor responses in human skin.
In: British Journal of Dermatology. 2009 ; Vol. 161, No. 4, OCT. p. 737-745

Gazerani, Parisa ; Pedersen, Natalia Spicina ; Ståhl, Camilla ; Drewes, Asbjørn Mohr ; Arendt-Nielsen, Lars.
Subcutaneous Botulinum toxin type A reduces capsaicin-induced trigeminal pain and vasomotor reactions in human skin.
In: Pain. 2009 ; Vol. 141, No. 1-2, JAN. p. 60-69

Ge, Hong You ; Nie, HongLing ; Madeleine, Pascal ; Danneskiold-Samsøe, Bente ; Graven-Nielsen, Thomas ; Arendt-Nielsen, Lars.
Contribution of the local and referred pain from active myofascial trigger points in fibromyalgia syndrome.
In: Pain. 2009 ; Vol. 147, No. 1-3, p. 233-240

Ge, Hong You ; Serrao, M. ; Andersen, Ole K. ; Graven-Nielsen, Thomas ; Arendt-Nielsen, Lars.
Increased H-reflex response induced by intramuscular electrical stimulation of latent myofascial trigger points.
In: Acupuncture in Medicine. 2009 ; Vol. 27, No. 4, p. 150-154

Ge, Hong You ; Wang, Ying ; Danneskiold-Samsøe, Bente ; Graven-Nielsen, Thomas ; Arendt-Nielsen, Lars.
The predetermined sites of examination for tender points in fibromyalgia syndrome are frequently associated with myofascial trigger points.
In: Journal of Pain. 2009 ; in press

Gibson, William; Arendt-Nielsen, Lars ; Sessle, Barry J. ; Graven-Nielsen, Thomas.
Glutamate and capsaicin-induced pain, hyperalgesia and modulatory interactions in human tendon tissue.
In: Experimental Brain Research. 2009 ; Vol. 194, No. 2, APR. p. 173-182

Gibson, William ; Arendt-Nielsen, Lars ; Taguchi, Toru ; Mizumura, Kazue ; Graven-Nielsen, Thomas.
Increased pain from muscle fascia following eccentric exercise : animal and human findings.
In: Experimental Brain Research. 2009 ; Vol. 194, No. 2, APR. p. 299-308

Gravesen, Flemming Holbæk ; Gregersen, Hans ; Arendt-Nielsen, Lars ; Drewes, Asbjørn Mohr.
Reproducibility of axial force and manometric recordings in the oesophagus during wet and dry swallows.
In: Neurogastroenterology and Motility. 2009 ; in press

Hedayatpour, Nosratollah ; Falla, Deborah Lorraine ; Arendt-Nielsen, Lars ; Farina, Dario.
Effect of delayed-onset muscle soreness on muscle recovery after a fatiguing isometric contraction.
In: Scandinavian Journal of Medicine & Science in Sports. 2009 ; in press

Hedayatpour, Nosratollah ; Falla, Deborah Lorraine ; Arendt-Nielsen, Lars ; Vila-Cha, Carolina ; Farina, Dario.
Motor unit conduction velocity during sustained contraction after eccentric exercise.
In: Medicine and Science in Sports and Exercise. 2009 ; Vol. 41, No. 10, OCT. p. 1927-1933

Herskin, Mette S. ; Ladewig, Jan ; Arendt-Nielsen, Lars.
Measuring cutaneous thermal nociception in group-housed pigs using laser technique-Effects of laser power output.
In: Applied Animal Behaviour Science. 2009 ; Vol. 118, No. 3-4, p. 144-151

Holst, H. ; Arendt-Nielsen, Lars ; Mosbech, H. ; Vesterhauge, S. ; Elberling, J..
The capsaicin cough reflex in patients with symptoms elicited by odorous chemicals.
In: International Journal of Hygiene and Environmental Health. 2009, in press

Jadidi, Faramarz ; Wang, Kelun ; Arendt-Nielsen, Lars ; Svensson, P..
Effect of stimulus parameters and contraction level on inhibitory responses in human jaw-closing muscles : implications for contingent stimulation.
In: Archives of Oral Biology. 2009 ; Vol. 54, No. 12, p. 1075-1082

Kimura, Y. ; Ge, Hong You ; Zhang, Y. ; Kimura, M. ; Sumikura, H. ; Arendt-Nielsen, L.
Evaluation of sympathetic vasoconstrictor response following nociceptive stimulation of latent myofascial trigger points in humans.
In: Acta Physiologica (Print Edition). 2009 ; Vol. 196, No. 4, AUG. p. 411-417

Komiyama, Osamu ; Wang, Kelun ; Svensson, Peter ; Arendt-Nielsen, Lars ; Kawara, Misao ; De Laat, Antoon.
Ethnic differences regarding sensory, pain, and reflex responses in the trigeminal region.
In: Clinical Neurophysiology. 2009 ; Vol. 120, No. 2, FEB. p. 384-389

Komiyama, Osamu ; Wang, Kelun ; Svensson, Peter ; Arendt-Nielsen, Lars ; De Laat, Antoon ; Uchida, Takashi ; Kawara, Misao.
Relation between electrical stimulus intensity, masseteric exteroceptive reflex and sensory perception.
In: Journal of Prosthodontic Research. 2009 ; Vol. 53, No. 2, p. 89-94

Koutris, M. ; Lobbezoo, F. ; Naeije, M. ; Wang, Kelun ; Svensson, Peter ; Arendt-Nielsen, Lars ; Farina, Dario.
Effects of intense chewing exercises on the masticatory sensory-motor system.
In: Journal of Dental Research. 2009 ; Vol. 88, No. 7, JUL. p. 658-662

La Touche, Roy ; Fernandez-de-las-Penas, Cesar ; Fernández-Carnero, Josué ; Díaz-Parreño, Santiago ; Paris-Alemany, Alba ; Arendt-Nielsen, Lars.
Bilateral mechanical-pain sensitivity over the trigeminal region in patients with chronic mechanical neck pain.
In: Journal of Pain. 2009 ; E-Pub ahead of print

Lelic, Dina ; Gratkowski, Maciej ; Valeriani, Massimiliano ; Arendt-Nielsen, Lars ; Drewes, Asbjørn Mohr.
Inverse modeling on decomposed electroencephalographic data : a way forward?
In: Journal of Clinical Neurophysiology. 2009 ; Vol. 26, No. 4, AUG. p. 227-235

Li, Lian-Tao ; Ge, Hong You ; Yue, Shou-Wei ; Arendt-Nielsen, Lars.
Nociceptive and non-nociceptive hypersensitivity at latent myofascial trigger points.
In: Clinical Journal of Pain. 2009 ; Vol. 25, No. 2, FEB. p. 132-137

Li, Xi ; Petrini, Laura ; Wang, Li ; Defrin, R. ; Arendt-Nielsen, Lars.
The importance of stimulus parameters for the experience of the thermal grill illusion.
In: Neurophysiologie Clinique. 2009 ; Vol. 39, No. 6, p. 275-282

Micalos, Peter S. ; Drinkwater, Eric J. ; Cannon, Jack ; Arendt-Nielsen, Lars ; Marino, Frank E..
Reliability of the nociceptive flexor reflex (RIII) threshold and association with Pain threshold.
In: European Journal of Applied Physiology. 2009 ; Vol. 105, No. 1, JAN. p. 55-62

Neziri, Alban Y. ; Curatolo, Michele ; Bergadano, Alessandra ; Petersen-Felix, Steen ; Dickenson, Anthony ; Arendt-Nielsen, Lars ; Andersen, Ole K..
New method for quantification and statistical analysis of nociceptive reflex receptive fields in humans.
In: Journal of Neuroscience Methods. 2009 ; Vol. 178, No. 1, MAR 30. p. 24-30

Neziri, Alban Y. ; Andersen, Ole K. ; Petersen-Felix, Steen ; Radanov, Bogdan ; Dickenson, Anthony H. ; Scaramozzino, Pasquale ; Arendt-Nielsen, Lars ; Curatolo, Michele.
The nociceptive withdrawal reflex : normative values of thresholds and reflex receptive fields.
In: European Journal of Pain. 2009 in press

Nie, HongLing ; Graven-Nielsen, Thomas ; Arendt-Nielsen, Lars.
Spatial and temporal summation of pain evoked by mechanical pressure stimulation.
In: European Journal of Pain. 2009 ; Vol. 13, No. 6, JUL. p. 592-599

Nie, HongLing ; Madeleine, Pascal ; Arendt-Nielsen, Lars ; Graven-Nielsen, Thomas.
Temporal summation of pressure pain during muscle hyperalgesia evoked by nerve growth factor and eccentric contractions.
In: European Journal of Pain. 2009 ; Vol. 13, No. 7, AUG. p. 704-710

O'Neill, Søren ; Graven-Nielsen, Thomas ; Manniche, Claus ; Arendt-Nielsen, Lars.
Ultrasound guided, painful electrical stimulation of lumbar facet joint structures : an experimental model of acute low back pain.
In: Pain. 2009 ; Vol. 144, No. 1-2, JUL. p. 76-83

Olesen, Anne Estrup ; Ståhl, Camilla ; Brock, Christina ; Arendt-Nielsen, Lars ; Drewes, Asbjørn Mohr.
Evoked human oesophageal hyperalgesia: : a potential tool for analgesic evaluation?
In: Basic & Clinical Pharmacology & Toxicology. 2009 ; Vol. 105, No. 2, AUG. p. 126-135

Peddireddy, Anitha ; Wang, Kelun ; Svensson, Peter ; Arendt-Nielsen, Lars.
Blink reflexes in chronic tension-type headache patients and healthy controls.
In: Clinical Neurophysiology. 2009 ; Vol. 120, No. 9, SEP. p. 1711-1716

Peddireddy, Anitha ; Wang, Kelun ; Svensson, Peter ; Arendt-Nielsen, Lars.
Stretch reflex and pressure pain thresholds in chronic tension-type headache patients and healthy controls. In:
Cephalalgia. 2009 ; Vol. 29, No. 5, MAY. p. 556-565

Petrini, Laura ; Hennings, Kristian ; Arendt-Nielsen, Lars.
The effect of visuo-spatial organisation in recognition-memory tasks.
In: Perception. 2009 ; Vol. 38, No. 5, p. 763-774

Pryseley, Assam ; Ledent, Edouard Y. ; Drewes, Asbjørn Mohr ; Ståhl, Camilla ; Olesen, Anne Estrup ; Arendt-Nielsen, Lars.
Applying concepts of generalizability theory on data from experimental pain studies to investigate reliability.
In: Basic & Clinical Pharmacology & Toxicology. 2009 ; Vol. 105, No. 2, AUG. p. 105-112

Spaich, Erika G. ; Emborg, Jonas ; Collet, Thomas ; Arendt-Nielsen, Lars ; Andersen, Ole K..
Withdrawal reflex responses evoked by repetitive painful stimulation delivered on the sole of the foot during late stance : site, phase, and frequency modulation.
In: Experimental Brain Research. 2009 ; Vol. 194, No. 3, APR. p. 359-368

Ståhl, Camilla ; Olesen, Anne Estrup ; Andresen, Trine ; Arendt-Nielsen, Lars ; Drewes, Asbjørn Mohr.
Assessing analgesic actions of opioids by experimental pain models in healthy volunteers : an updated review.
In: British Journal of Clinical Pharmacology. 2009 ; Vol. 68, No. 2, AUG. p. 149-168
Ståhl, Camilla ; Olesen, Anne Estrup ; Andresen, Trine ; Arendt-Nielsen, Lars ; Drewes, Asbjørn Mohr.
Assessing efficacy of non-opioid analgesics in experimental pain models in healthy volunteers : an updated review.
In: British Journal of Clinical Pharmacology. 2009 ; Vol. 68, No. 3, SEP. p. 322-341

Trojan, Jörg ; Kleinböhl, Dieter ; Stolle, Annette M. ; Andersen, Ole K. ; Hölzl, Rupert ; Arendt-Nielsen, Lars.
Independent psychophysical measurement of experimental modulations in the somatotopy of cutaneous heat-pain stimuli.
In: Somatosensory and Motor Research. 2009 ; Vol. 26, No. 1, p. 11-17

You, Hao-Jun ; Lei, Jing ; Arendt-Nielsen, Lars.
Selective inhibitory effects of pregabalin on peripheral C but not A-δ fibers mediated nociception in intact and spinalized rats.
In: Neuroscience. 2009 ; Vol. 164, No. 4, p. 1845-1853

Zhang, Yang ; Ge, Hong You ; Yue, Shou-Wei ; Kimura, Yoshiyuki ; Arendt-Nielsen, Lars.
Attenuated skin blood flow response to nociceptive stimulation of latent myofascial trigger points.
In: Archives of Physical Medicine and Rehabilitation. 2009 ; Vol. 90, No. 2, FEB. p. 325-332

Fernández-de-las-Peñas, C. ; Madeleine, Pascal ; Caminero, A. B. ; Cuadrado, M. L. ; Arendt-Nielsen, Lars ; Pareja, J. A..
Generalized neck-shoulder hyperalgesia in chronic tension-type headache and unilateral migraine assessed by pressure pain sensitivity topographical maps of the trapezius muscle.
In: Cephalalgia. 2009 ; E-Pub ahead of print

Arendt-Nielsen, Lars ; Falla, Deborah Lorraine.
Motor control adjustments in musculoskeletal pain and the implications for pain recurrence.
In: Pain. 2009 ; Vol. 142, No. 3, APR. p. 171-172

EB Dam, I Byrjalsen, MA Karsdal, P Qvist, C Christiansen.
Increased urinary excretion of C-telopeptides of type II collagen (CTX-II) predicts cartilage loss over 21 month by MRI.
In: Osteoarthritis and Cartilage, 2009, 17, 384-389.

NH Bjarnason, TF Nielsen, HL Jørgensen, C Christiansen.
The influence of smoking and bone loss and response to nasal estradiol.
In: Climacteric 2009; 12: 59-65

Henrik Rasmussen, Yu Bagger, Laszlo B. Tanko, Claus Christiansen and Thomas Werge.
Lack of Association of the Serotonin Transporter Gene Promoter Region Polymorphism, 5-HTTLPR, incliding rs25531 with cigarette smoking and alcohol consumption.
In: American Journal of Medical Genetics, part B 150B:575-580, 2009

Morten A. Karsdal, Inger Byrjalsen, Möise Azria, Michel Arnold, Les Choi, Bente J. Riis, Claus Christiansen.
Influence of food intaken on the bioavailability and efficacy of oral Calcitonin.
In: BJCP, 67:4, 413-420, 2009

Mads Nielsen, Jakob Raundahl, Paola C. Pettersen, Marco Loog, Gopal Karemore, Morten A. Karsdal, Claus Christiansen.
Low-dose transdermal estradiol induces breast density and heterogeneity changes comparable to those of raloxifene.
In: The Journal of the Northe American Menopause Society, vol 16, no. 4, pp:785-791, 2009

Morten A. Karsdal, Inger Byrjalsen, Kim Henriksen, Bente J. Riis, Claus Christiansen.
A Pharmacokinetic and Pharmacodynamic Comparison of Synthetic and Recombinant Oral Salmon Calcitonin.
In: The Journal of Clinical Pharmacology, 49; 229, 2009

Erik B Dam, Marco Loog, Claus Christiansen, Inger Byrjalsen, Jenny Folkesson, Mads Nielsen, Arish A Qazi, Paola C Pettersen, Patrick Garnero, Morten A Karsda.
Identification of progressors in osteoarthritis by combining biomedical and MRI-based markers.
In: Arthritis Research & Therapy, 11: R1 15, 2009

Serge Rozenberg, Bruno Pornel, Philippe R. Koninckx, Santiago Palacios, Claus Christiansen.
Endometrium protection and acceptability of nasally administered continuously combined hormone therapy: a multicentre, multinational, double-blind trial in post-menopausal women evaluating three
regimens of 17β-estradiol and norethisterone when compared with an orally administered 17β-estradiol norethisterone regimen.
In: Human reproduction, Vol 24, no. 7, pp. 1739-1749, 2009

Bo Li, Inger Byrjalsen, Paul Glendenning, Dennis B. Henriksen, Hans C. Hoeck, Mario Taranto, Samuel Vasikaran, Wiliam D. Fraser, Claus Christiansen, Per Qvist.
Selective monitoring of vitamin D2 and D3 supplementation with a highly specific 25-hydroxyvitamin D3 immunoassay with negligible cross-reactivity to 25-hydroxyvitamin D2.
In: Clinical Chimica Acta, 404, 144-148, 2009

M.A. Karsdal, K. Henriksen, D.J. Leeming, P. Mitchell, K. Duffin, N. Barascuk, L. Klickstein, P. Aggarwal, O. Nemirovskiy, I. Byrjalsen, P. Qvist, A.C. Bay-Jensen, E.B. Dam, S.H. Madsen, C. Christiansen.
Biomedical Markers and the FDA Critical Path:
In: How biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development Biomarkers, 14(3): 181-202, 2009

Arendt-Nielsen, Lars ; Rosetzsky, Allan ; Weidner, Morten Sloth.
A double-blind randomized placebo controlled parallel group study demonstrates analgesic effects of sheanut oil extract (BSP-201) in exercise induced muscle tenderness.
In: Journal of Musculoskeletal Pain. 2009 ; Vol. 17, No. 1, p. 8-14

T. Segovia-Silvestre, A.V. Neutzsky-Wulff, M.G. Sørensen, C. Christiansen, J. Bollerslev, M.A. Karsdal, K. Henriksen.
Advances in osteoclast biology resulting from the study of osteopetrotic mutations.
In: Hum Gentet, 124: 561-577, 2009

Kim Henriksen, Iger Byrjalsen, Rasmus H. Nielsen, Andreas N. Madsen, Leif K. Larsen, Claus Christiansen, Henning Beck-Nielsen, Morten A. Karsdal.
A comparison of glycemic control, wather retention, and musculoskeletal effects of balagitazone and piogliazone in diet-induced obese rats.
In: European Journal of Pharmacology 161; 340-345, 2009

Gudmar Thorleifsson, Hilma Holm, Vidar Edvardsson, G. Bragi Walters, Unnur Styrkarsdottir, Daniel F. Gudbjartsson, Patrik Sulem, Bjarni V. Halldorsson, Femmi de Vegt, Frank C.H. d´Ancona, Martin den
Heijer, Leifur Frantzon, Claus Christiansen, Peter Alexandersen, Thorunn Rafnar, Kristleifur Kristjansson, Gunnar Sigurdsson, Lambertus A. Kienebey, Magnus Bodvarsson, Olafur S. Indridason, Runolfur
Palsson, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson.
Sequence varients in the CLDN14 gene associated with kidney stones and bone mineral density.
In: Nature Genetics, Vol. 41, no. 8, 2009

Steve R. Cummings, Javir San Martin, Michael R. McClung, Ethel S. Siris, Richar Eastell, Ian R. Reid, Pierre Delams, Holly B. Zoog, Matt Austin, Andrea Wang, Stepan Kutilek, Silvano Adami, Jose Zanchetta,
Cesar Libanati, Suresh Siddhanti, Claus Christiansen
– for the FREEDOM Trial Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis.
In: NEJM, 361;8, 2009

Matthias Schaefers, Christoph Muyers, Peter Alexandersen, Claus Chrisitansen.
Effect of microdose transdermal 17β-estradiol compared with raloxifene in the prevention of bone loos in healthy postmenopausal women: a 2-year, randomized, bouble-blind trial.
In: The journal of the North American Menopause Society, vol 6, no 3, pp 559-565, 2009

Dennis B. Henriksen, Peter Alexandersen, Bolette Hartmann, Charlotte L. Adrian, inger Byrjalsen, henry G. Bone, Jens J. Holst, Claus Christiansen.
Four-month treatment with GLP-2 significantly increases hip BMD. A randomized, placebo-contolled, dose-ranging study in postmenopausal women with low BMD.
In: Bone 45, 833-842. 2009

Unnur Styrkardottir, Bjarni V halldorsson, Solveig Getarsdottir, Daniel F. Gudbjartsson, G. Bragi Walters, Thorvalddur Ingvarsson, Thorbjorg Jonsdottir, Jona Saemiúndsdottir, Steinunn Snorradóttir, Jacquline R
Center, Tua V Nguyen, Peter Alexandersen, Jeffery R. Gulcher, John A. Eisman, Claus Christiansen, Gunnar Sigurdsson, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson.
New Sepuence variants associated with bone mineral density.
In: Nature Genetics, Brief communications, Vol. 4, no. 1, January 2009.

Patrick Sulem, Daniel F. Gudbjartsson, Thorunn Rafnar, Hilma Holm, Elinborg J Olafsdottir, Gudridur H Olafsdottir, Thorvaldur Jonsson, Peter Alexandersen, Bjarke Feenstra, Heather A Boyd, Katja K Aben,
Andre L M Verbeek, Nel Roeleveld, Aslaug jonasdottir, Unnur Styrkarsdottir, Valgerdur Steinthorsdottir, Ari Karason, Simon N Stacey, Julius Gudmundsson, Margret Jakobsdottir, Gudmar Thorleifsson,
Gudmundur Hardarson, Jeffery Gulcher, Augustine Kong, Lambertus A Kiemeney, mads Melby, Claus Christiansen, Laufey Tryggvadottir, Unnur Thorsteinsdottir, kari Stefansson.
Genome-wide association study identifies sequence variants on 6q21 associated with age at merarche.
In: Nature genetics Letter, vol 41, no. 6, June 2009.

Peter Alexandersen, Moren A Karsdal, Claus Christiansen.
Long-term prevention with hormone-replacement therapy after the menopause: Which women should be targeted?
In: Womens Health, 5(6), 637-647, 2009.

Li B, Byrjalsen I, Glendenning P, Henriksen DB, Hoeck HC, Taranto M, Vasikaran S, Fraser WD, Christiansen C, Qvist P.
Selective monitoring of vitamin D(2) and D(3) supplementation with a highly specific 25-hydroxyvitamin D(3) immunoassay with negligible cross-reactivity to 25-hydroxyvitamin D(2).
In: Clin Chim Acta. 2009;404:144-48.

Ovesen J, Møller-Madsen B, Nielsen PT, Christensen PH, Simonsen O, Hoeck HC, Laursen MB, Thomsen JS.
Differences in zinc status between patients with osteoarthritis and osteoporosis.
In: J Trace Elem Med Biol. 2009;23(1):1-8.

Hoeck HC, Li B, Qvist P.
Changes in 25-Hydroxyvitamin D3 to oral treatment with vitamin D3 in postmenopausal females with osteoporosis.
In: Osteoporos Int. 2009;20:1329-35.

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