Phase II pain trials
The C4Pain strategy is to obtain pain mechanism related date from patients using pain bio-marker together with clinical measures to qualify go/no-go decisions and to be optimally qualified for selecting patients for later clinical trials, i..e selecting the most optimal primary outcome parameters.
Such studies can be done for single dose, multiple dosing or in dose escalation studies. Adding experimental pain measures in such studies are for free at they can be done in addition to sampling the clinical efficacy data.