Translating experimental pain data
The C4Pain multi-modal, multi-tissue, multi-mechanism pain assessment paradigm for profiling new and existing compounds includes induction and assessment of peripheral, spinal and supra-spinal mechanisms.
The acquired mechanism related knowledge and target validation transferred from one trial to the other ensures the most optimal primary outcome parameter is selected and the pain mechanisms of importance thoroughly evaluated (target validation) at all phases of development providing more successful development programs.
Such studies qualify the decision of which patient (sub-) population should be selected for later large clinical trials.