Trial design and interpretation
Although pre-clinical data on drug efficacy only sparsely resemble the effects in pain patients C4Pain use the available data to design human proof-of-concept studies (forward-translation) and may suggest clients to acquire additional pre-clinical information (back-translation).
The C4Pain research based approach may suggest back-translation of human pain bio-markers to closer mimic the pre-clinical models to the human conditions. If needed C4Pain develops and validates new human pain bio-markers.
C4pain constantly enlarge its library of already mechanism based profiled compounds and hence new compounds within the same class of already profiled compounds provides valuable insight into which human pain bio-markers may be the most sensitive. This significantly enhances the chances for success when trials are designed and bio-markers and clinical pain parameters are selected. No other CRO in the world has such a comprehensive service to offer.
This knowledge is applied in design and protocol development. After trial completion C4Pain offers state-of-the art interpretation of the results.